The research themes being addressed by CAMO-Net are based on an extensive process of international consensus and the development of a commissioned research roadmap and subsequent key opinion building Lancet European Health publication in 2021.
Technology and innovation
Context, culture, and behaviours
Medicines management
Essential data infrastucture
Funded by
Wellcome
Technology and innovation for optimised prescribing, which includes:
- Artificial intelligence (AI), including machine learning, for individual and population-level clinical decision support, data and diagnostics, and integrating host and pathogen dynamics
- Point of care (PoC) and laboratory-based diagnostics, lab-on-chip technology, antimicrobial biosensing and drug sensing for medicine quality
- Use of data, including standardised pooling
- Innovation adoption and implementation.
Context, culture and behaviours which includes (i) organisational and individual behaviour change; (ii) health-seeking and health provision behaviours; and (iii) intersection of the socio-cultural determinants of health and health literacy with AMR.
Medicines management, which includes:
- Supply chains and distribution, addressing and forecasting shortages
- Prescribing systems and monitoring frameworks
- Quality assurance testing
- Addressing comorbidities, polypharmacy, and drug-drug
interactions.
Data intelligence
Data from partnerships with industry (IQVIA) and not-for-profit organisations (ProMED-AMR) will be made available to enhance the research in these themes and provide expert local intelligence.
Essential data infrastructure
Nowhere in the world exists a collated and standardised repository for antimicrobial pharmacokinetic-pharmacodynamic (PK-PD) and other antimicrobial optimisation-related data. CAMO-Net will develop a sustainable open-source central data repository where data collected from multiple investigators and studies can be stored and curated for the longer term. Using PK-PD data as an entry point, the proposed CAMO Global Data Resource (CAMO-GDR) will enable data to be combined, analysed and reanalysed. It will also
facilitate high-quality studies, education and training.
Key deliverables of CAMO-Net
Our vision is a world where the appropriate, evidence-based use of antimicrobials is commonplace, supported by equitable availability and accessibility. Here’s how we will achieve our vision:
- Establish an integrated global approach to antimicrobial optimisation via a sustainable structure with global representation and leadership as well as shared learning
- Gain new knowledge/information on antimicrobial prescribing and use
- Grow our national policy influence across each national hub with regard to antimicrobial optimisation across technology innovation; context, culture and behaviours, and medicines management
- Develop CAMO-GDR as an open resource with curated data and models to underpin an understanding of the emergence of AMR.